Firebird has expanded the genetic alphabet by creating AEGIS to solve the problem of interference when detecting DNA in complex biological media.

By shuffling the hydrogen bond donors and acceptors of standard bases, Firebird has created heterocycles that implement additional hydrogen bonding patterns for the Z:P and S:B base pairs as shown below.  These base pairs are “orthogonal” to CG and AT.

Benner, 2004; Hoshika et al., 2019; Sefah et al., 2014; Yang et al., 2006